Diuretic activity and mechanism of N-[3’-sulfamoyl-4’-chlorobenzamide)-2-methylindoline (SE-1520) as a new hypotensive diuretic agent (1)
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Diuretic activity of 3-N-butylamino-4-phenoxy-5-sulphamyl benzoic acid (bumetanide) in hamster.
Bumetanide is a 3-aminobenzoic acid derivative. Of the several analogues having various substituents which are about equally active in test animals (3). Ostergaard elal. (5) selected 3-n-butylamino-4-phenoxy·5-sulphamyl benzoic acid (bumetanide) and studied its pharmacological properties. including its diuretic action in rats and dogs. Besides the diuretic effect bumetanide displayed hardly any...
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Diuretics are the agents which cause increase in excretion of urine. Diabetes mellitus (DM) is a multi-factorial disorder characterized by hyperglycemia resulting from an increased hepatic glucose production and diminished insulin secretion. The present study was undertaken to study the diuretic and anti-diabetic activity of esculin. Esculin was found to have potent diuretic activity in normal ...
متن کاملAtriopeptin III. A potent natriuretic, diuretic, and hypotensive agent in rats with chronic renal failure.
Chronic renal failure is frequently associated with volume overload, resulting in hypertension and, in some cases, congestive heart failure. Atriopeptin III (AP III), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent in normal rats. An infusion of AP III at 0.2 microgram/kg per min for 60 min produced dramatic responses in animals with chronic renal failure ...
متن کاملA NEW ORAL MERCURIAL DIURETIC - MERPURATE TABLE 4 . - Dog Urinalysis
OU RAL administration of diuretics with a safe and satisfactory diuresis has always been a therapeutic goal. Diuresis could then be accomplished at a slow but regular rate, with the avoidance of a sudden profuse diuresis,' which is very uncomfortable for the patient, and produces marked alteration of the fluid and electrolyte balance. Rapid diuresis has been known to cause attacks of gout,2 tet...
متن کاملA NEW ORAL MERCURIAL DIURETIC - MERPURATE TABLE 4 . - Dog
OU RAL administration of diuretics with a safe and satisfactory diuresis has always been a therapeutic goal. Diuresis could then be accomplished at a slow but regular rate, with the avoidance of a sudden profuse diuresis,' which is very uncomfortable for the patient, and produces marked alteration of the fluid and electrolyte balance. Rapid diuresis has been known to cause attacks of gout,2 tet...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1976
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66148-2